Cognitive Scores and Selected Polyunsaturated Fatty Acids in Adolescents With Depression in Sokoto
DOI:
https://doi.org/10.30787/gaster.v24i2.2398Keywords:
Adolescents, Cognition, Depression, Polyunsaturated fatty acids, NigeriaAbstract
Introduction: Polyunsaturated fatty acids (PUFAs) participate in neuronal functions, but their relationship with cognitive outcomes among adolescents with depression remains uncertain.
Objective: To compare cognitive screening scores between adolescents with reported depression and healthy participants and describe available PUFA measurements in Sokoto, Nigeria.
Method: This cross-sectional comparison included 30 adolescents with reported depression and 25 comparison participants. Cognitive screening was described using a mini-mental-state instrument, and selected fatty-acid values were reported for the depression group. An independent-samples t-test was reported.
Result: Mean cognitive scores were 21.50 ± 0.94 and 26.72 ± 3.048 in the depression and comparison groups, respectively (reported t = 8.31; p = 0.001). Four PUFA summary values were available only for the depression group, without units or reference intervals.
Conclusion: Lower cognitive screening scores were reported in the depression group. The available data do not establish PUFA deficiency or an association between PUFA status and cognition; methodological and biochemical verification is required.
References
Schumacher A, Campisi SC, Khalfan AF, Merriman K, Williams TS, Korczak DJ. Cognitive functioning in children and adolescents with depression: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2024;79:49-58. https://doi.org/10.1016/j.euroneuro.2023.11.005
Bondi CO, Taha AY, Tock JL, Totah NKB, Cheon Y, Torres GE, et al. Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency. Biol Psychiatry. 2014;75(1):38-46. https://doi.org/10.1016/j.biopsych.2013.06.007
Zhou X, Xiong H, Chai Y, Huang Y, Tang Z, Zhang H, et al. Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system. Front Psychiatry. 2022;13:933704. https://doi.org/10.3389/fpsyt.2022.933704
da Fonseca FCP, Mucci DB, Assumpcao RP, Marcondes H, Sardinha FLC, Silva SV, et al. Differential long-chain polyunsaturated fatty acids status and placental transport in adolescent pregnancies. Nutrients. 2018;10(2):220. https://doi.org/10.3390/nu10020220
Mongan D, Healy C, Jones HJ, Zammit S, Cannon M, Cotter DR. Plasma polyunsaturated fatty acids and mental disorders in adolescence and early adulthood: cross-sectional and longitudinal associations in a general population cohort. Transl Psychiatry. 2021;11:321. https://doi.org/10.1038/s41398-021-01425-4
Wang M, Yan X, Li Y, Li Q, Xu Y, Huang J, et al. Association between plasma polyunsaturated fatty acids and depressive among US adults. Front Nutr. 2024;11:1342304. https://doi.org/10.3389/fnut.2024.1342304
Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, Korczak D. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. https://doi.org/10.1002/14651858.CD014803.pub2
Zailani H, Wang WL, Satyanarayanan SK, Chiu WC, Liu WC, Sung YS, et al. Omega-3 polyunsaturated fatty acids and blood-brain barrier integrity in major depressive disorder: restoring balance for neuroinflammation and neuroprotection. Yale J Biol Med. 2024;97(3):349-363. https://doi.org/10.59249/YZLQ4631
Zung WWK. A self-rating depression scale. Arch Gen Psychiatry. 1965;12(1):63-70. https://doi.org/10.1001/archpsyc.1965.01720310065008
Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-198. https://doi.org/10.1016/0022-3956(75)90026-6
Li Y, Hua L, Ran Q, Gu J, Bao Y, Sun J, et al. Plasma polyunsaturated fatty acid levels and mental health in middle-aged and elderly adults. Nutrients. 2024;16(23):4065. https://doi.org/10.3390/nu16234065
Oliveira ORC, Santana MG, Santos FS, Conceicao FD, Sardinha FLC, Veiga GV, et al. Composition of fatty acids in the maternal and umbilical cord plasma of adolescent and adult mothers: relationship with anthropometric parameters of newborn. Lipids Health Dis. 2012;11:157. https://doi.org/10.1186/1476-511X-11-157
Flannagan KS, Gahagan S, Das AK, Burrows RA, Lozoff B, Villamor E. Serum polyunsaturated fatty acids in middle childhood are associated with body mass index change through adolescence. Ann Nutr Metab. 2019;75(1):77-85. https://doi.org/10.1159/000502077
Gabbay V, Freed RD, Alonso CM, Senger S, Stadterman J, Davison BA, et al. A double-blind placebo-controlled trial of omega-3 fatty acids as a monotherapy for adolescent depression. J Clin Psychiatry. 2018;79(4):17m11596. https://doi.org/10.4088/JCP.17m11596
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Bull World Health Organ. 2007;85(11):867-872. https://doi.org/10.2471/BLT.07.045120
Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry. 2006;163(6):1098-1100. https://doi.org/10.1176/ajp.2006.163.6.1098
Reily NM, Tang S, Negrone A, Gan DZQ, Sheanoda V, Christensen H. Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: a scoping review. PLoS One. 2023;18(4):e0284057. https://doi.org/10.1371/journal.pone.0284057
Dyall SC, Malau IA, Su KP. Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials. Curr Opin Clin Nutr Metab Care. 2025;28(2):66-74. https://doi.org/10.1097/MCO.0000000000001077
Setyo Handryastuti RA, Agustina NN, Sekartini R, Sari TT, Mangunatmadja I, Tridjaja B, et al. The validity and reliability test of the mini-mental state pediatric examination (MMSPE) as a screening instrument for cognitive function in Indonesian-speaking children. BMC Pediatr. 2025;25:877. https://doi.org/10.1186/s12887-025-06021-9
Kolodziej L, Czarny PL, Ziolkowska S, Bialek K, Szemraj J, Galecki P, et al. How fish consumption prevents the development of major depressive disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF. Prog Lipid Res. 2023;92:101254. https://doi.org/10.1016/j.plipres.2023.101254
Chang JPC, Su KP. Nutritional neuroscience as mainstream of psychiatry: the evidence-based treatment guidelines for using omega-3 fatty acids as a new treatment for psychiatric disorders in children and adolescents. Clin Psychopharmacol Neurosci. 2020;18(4):469-483. https://doi.org/10.9758/cpn.2020.18.4.469
Borsini A, Alboni S, Horowitz MA, Tojo LM, Cannazza G, Su KP, et al. Rescue of IL-1beta-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants. Brain Behav Immun. 2017;65:230-238. https://doi.org/10.1016/j.bbi.2017.05.006
Stachowicz K. The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes. Arch Biochem Biophys. 2023;737:109555. https://doi.org/10.1016/j.abb.2023.109555
Wen J, Satyanarayanan SK, Li A, Yan L, Zhao Z, Yuan Q, et al. Unraveling the impact of omega-3 polyunsaturated fatty acids on blood-brain barrier integrity and glymphatic function. Brain Behav Immun. 2024;115:335-355. https://doi.org/10.1016/j.bbi.2023.10.018
Cornu C, Mercier C, Ginhoux T, Masson S, Mouchet J, Nony P, et al. A double-blind placebo-controlled randomised trial of omega-3 supplementation in children with moderate ADHD symptoms. Eur Child Adolesc Psychiatry. 2018;27(3):377-384. https://doi.org/10.1007/s00787-017-1058-z
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